In this module, dynamic models are used to explore how proteins fold into specific shapes. You will also learn what causes a protein to lose its ability to function, and about molecular diseases associated with changes in structure.
Activity 1 - How a Protein Gets Its Shape: Charged Amino Acids
*Background:The Case of Sickle Cell Anemia
*Background:The Structure of Amino Acids in Proteins
*Worksheet: Amino Acid and Charge
(Homework for next activity) *How do Amino Acids React to Water and Oil?
Activity 2 - How a Protein Gets its Shape: The Role of Water and Lipids
(Homework from last activity) *How Do Amino Acids React to Water or Lipids
*Worksheet: How a Protein Gets it Shape: Responding to Water or Lipids
Activity 3 - How a Protein Gets its Shape: The Role of DNA as Code
* Background: From DNA to RNA to Protein
* Worksheet: From Genetic Code to Protein Structure Worksheet
Activity 4 - Protein Malfunction and Disease
* Background: Molecular Machines and Tools Chart
* Worksheet: Mutation
* Worksheet: Protein Malfunction and Disease: Making a Sickle Cell Mutation